Guardian Therapeutics
Bringing to life the full potential of aptamer therapeutics.
Aptamers
- Aptamers are short nucleic acids that bind to a specific target molecule
- The word aptamer comes from the Latin aptus meaning fit
- At the molecular level, aptamers bind to their target site through electrostatic interactions, hydrophobic interactions, and their complementary shapes
- Aptamers have been discovered that are specific to small molecules, proteins, nucleic acids, cells, tissues and organisms
BT100 aptamer:vWF A1 domain complex
ApDC
Aptamer Drug Conjugates: A Novel Targeted Delivery Platform for Oncology
Targeted therapy modality in which aptamers replace mAbs in drug conjugates
Have target specificity and affinity on par with mAbs
Can be selected for inhibitory, stimulatory, or no biological activity
Support receptor-mediated internalization
Different aptamers may be joined to form bi-specific therapeutic agents
Contact
© 2021 Guardian Therapeutics. All rights reserved.
Headquarters
Guardian Therapeutics
101 Hartwell Avenue
Suite 2
Lexington, MA 02421
+1 (781) 918-6580
General Inquiries:
info@guardian-rx.com
Business Development Inquiries: businessdevelopment@guardian-rx.com